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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552436
Species: Mus musculus
RGD Object: Gene
Symbol: Pdcd1lg2
Name: programmed cell death 1 ligand 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdcd1lg2decreases expressionISORGD:13149986480464CTDCisplatin results in decreased expression of PDCD1LG2

PMID:21765211
Pdcd1lg2multiple interactionsISORGD:13149986480464CTDCisplatin inhibits the reaction [[TNF co-treated with IL4] results in increased expression of PDCD1LG2], Cisplatin inhibits the reaction [[TNF co-treated with Lipopolysaccharides] results in increased expression of PDCD1LG2]

PMID:21765211
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.