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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552084
Species: Mus musculus
RGD Object: Gene
Symbol: Mapkapk3
Name: mitogen-activated protein kinase-activated protein kinase 3
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapkapk3increases expressionEXP 6480464CTDCisplatin results in increased expression of MAPKAPK3 mRNAPMID:25270620
Mapkapk3increases expressionISOMAPKAPK3 (Homo sapiens)6480464CTDCisplatin results in increased expression of MAPKAPK3 mRNAPMID:27392435
Mapkapk3multiple interactionsISOMAPKAPK3 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of MAPKAPK3 mRNAPMID:27392435
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