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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359491
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pou5f1
Name: POU class 5 homeobox 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pou5f1increases expressionISOPOU5F1 (Homo sapiens)6480464CTDCisplatin results in increased expression of POU5F1 mRNA; Cisplatin results in increased expression of POU5F1 proteinPMID:20074550 PMID:21618587 PMID:33545341 PMID:33969609
Pou5f1multiple interactionsISOPOU5F1 (Homo sapiens)6480464CTD[Cisplatin co-treated with Paclitaxel] results in increased expression of POU5F1 mRNA; [Cisplatin co-treated with Paclitaxel] results in increased expression of POU5F1 protein; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of POU5F1 mRNA; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of POU5F1 protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of POU5F1 proteinPMID:20705681 PMID:21342274 PMID:30291867
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