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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases expressionEXP 6480464CTDCisplatin results in increased expression of HSPA1A mRNAPMID:19561079 PMID:27392435
HSPA1Amultiple interactionsEXP 6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of HSPA1A mRNA; Cisplatin affects the reaction [Piroxicam results in decreased expression of HSPA1A mRNA]PMID:21858171 PMID:27392435
HSPA1Adecreases expressionISOHspa1a (Rattus norvegicus)6480464CTDCisplatin results in decreased expression of HSPA1A proteinPMID:12690470
HSPA1Aincreases expressionISOHspa1a (Rattus norvegicus)6480464CTDCisplatin results in increased expression of HSPA1A mRNAPMID:18172885 PMID:22023808
HSPA1Amultiple interactionsISOHspa1a (Rattus norvegicus)6480464CTDsodium arsenite inhibits the reaction [Cisplatin results in decreased expression of HSPA1A protein]; uranyl acetate inhibits the reaction [Cisplatin results in decreased expression of HSPA1A protein]PMID:12690470
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