Gene Chemical Interaction Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1348077
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	CASP12
Name:	caspase 12 (gene/pseudogene)

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
CASP12	multiple interactions	EXP		6480464	CTD	[vorinostat co-treated with Cisplatin] results in increased activity of CASP12 protein	PMID:19280190
CASP12	affects cleavage	ISO	Casp12 (Rattus norvegicus)	6480464	CTD	Cisplatin affects the cleavage of CASP12 protein	PMID:20071420
CASP12	increases cleavage	ISO	Casp12 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased cleavage of CASP12 protein	PMID:33631298
CASP12	increases cleavage	ISO	Casp12 (Mus musculus)	6480464	CTD	Cisplatin results in increased cleavage of CASP12 protein	PMID:16357177 PMID:21616140
CASP12	increases expression	ISO	Casp12 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of CASP12 mRNA; Cisplatin results in increased expression of CASP12 protein	PMID:23603837 PMID:33631298
CASP12	multiple interactions	ISO	Casp12 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased cleavage of and results in increased activity of CASP12 protein; Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of CASP12 mRNA]; Eicosanoids analog inhibits the reaction [Cisplatin results in increased expression of CASP12 protein]; ursodoxicoltaurine inhibits the reaction [Cisplatin results in increased cleavage of CASP12 protein]; ursodoxicoltaurine inhibits the reaction [Cisplatin results in increased expression of CASP12 mRNA]	PMID:17567590 PMID:23603837 PMID:33631298
CASP12	multiple interactions	ISO	Casp12 (Mus musculus)	6480464	CTD	[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of CASP12 mRNA; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]]; salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]	PMID:21616140 PMID:23625948

Go Back to source page

Continue to Ontology report