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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345199
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC1A4
Name: solute carrier family 1 member 4
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC1A4decreases expressionEXP 6480464CTDCisplatin results in decreased expression of SLC1A4 mRNAPMID:25596134
SLC1A4increases expressionEXP 6480464CTDCisplatin results in increased expression of SLC1A4 mRNAPMID:27594783
SLC1A4decreases phosphorylationISOSlc1a4 (Mus musculus)6480464CTDCisplatin results in decreased phosphorylation of SLC1A4 proteinPMID:22006019
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