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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343267
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP13
Name: matrix metallopeptidase 13
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP13increases expressionEXP 6480464CTDCisplatin results in increased expression of MMP13 proteinPMID:37497868
MMP13multiple interactionsEXP 6480464CTD6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cisplatin results in increased expression of MMP13 protein]; PPARGC1A protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in increased expression of MMP13 protein]]; SRT1720 inhibits the reaction [Cisplatin results in increased expression of MMP13 protein]PMID:37497868
MMP13decreases expressionISOMmp13 (Mus musculus)6480464CTDCisplatin results in decreased expression of MMP13 mRNAPMID:29148169
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