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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322414
Species: Mus musculus
RGD Object: Gene
Symbol: Slc47a1
Name: solute carrier family 47, member 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc47a1affects transportEXP 6480464CTDSLC47A1 protein affects the transport of CisplatinPMID:24001450
Slc47a1increases response to substanceEXP 6480464CTDSLC47A1 gene mutant form results in increased susceptibility to CisplatinPMID:24001450
Slc47a1multiple interactionsEXP 6480464CTDSLC47A1 gene mutant form promotes the reaction [Cisplatin results in increased expression of HAVCR1 mRNA]; SLC47A1 gene mutant form promotes the reaction [Cisplatin results in increased expression of LCN2 mRNA]PMID:24001450
Slc47a1increases expressionISOSLC47A1 (Homo sapiens)6480464CTDCisplatin results in increased expression of SLC47A1 mRNAPMID:27392435
Slc47a1multiple interactionsISOSLC47A1 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of SLC47A1 mRNAPMID:27392435
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