GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | increases expression | EXP | | 6480464 | CTD | Cisplatin results in increased expression of SIRT1 protein | PMID:26723870 | Sirt1 | multiple interactions | EXP | | 6480464 | CTD | Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein; NQO1 gene mutant form inhibits the reaction [Cisplatin results in increased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]] | PMID:21593185 PMID:26723870 | Sirt1 | decreases activity | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | Cisplatin results in decreased activity of SIRT1 protein | PMID:33661552 | Sirt1 | decreases expression | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | Cisplatin results in decreased expression of SIRT1 mRNA | PMID:33522649 PMID:33661552 | Sirt1 | decreases expression | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | Cisplatin results in decreased expression of SIRT1 protein | PMID:37497868 | Sirt1 | decreases response to substance | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | SIRT1 protein results in decreased susceptibility to Cisplatin | PMID:21416250 | Sirt1 | increases expression | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | Cisplatin results in increased expression of SIRT1 protein | PMID:21416250 | Sirt1 | multiple interactions | ISO | Sirt1 (Rattus norvegicus) | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [betanin inhibits the reaction [Cisplatin results in decreased activity of SIRT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [betanin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA]]; 7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA]; betanin inhibits the reaction [Cisplatin results in decreased activity of SIRT1 protein]; betanin inhibits the reaction [Cisplatin results in decreased expression of SIRT1 mRNA] | PMID:33522649 PMID:33661552 | Sirt1 | multiple interactions | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | [Cisplatin co-treated with jinfukang] results in decreased expression of SIRT1 mRNA; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of SIRT1 mRNA | PMID:27392435 PMID:30871063 | |
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