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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317355
Species: Homo sapiens
RGD Object: Gene
Symbol: WEE1
Name: WEE1 G2 checkpoint kinase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
WEE1decreases response to substanceEXP 6480464CTDWEE1 protein results in decreased susceptibility to CisplatinPMID:34664776
WEE1multiple interactionsEXP 6480464CTD[[SNAP47 mRNA alternative form results in decreased expression of MIR625 mRNA] which results in increased expression of WEE1 protein] which results in decreased susceptibility to Cisplatin; [Cisplatin co-treated with jinfukang] results in decreased expression of WEE1 mRNAPMID:27392435 PMID:34664776
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