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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314756
Species: Homo sapiens
RGD Object: Gene
Symbol: TLN1
Name: talin 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TLN1affects response to substanceEXP 6480464CTDTLN1 protein affects the susceptibility to CisplatinPMID:21720550
TLN1increases response to substanceEXP 6480464CTDTLN1 protein results in increased susceptibility to CisplatinPMID:21291860
TLN1multiple interactionsEXP 6480464CTDTLN1 protein promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased susceptibility to Cisplatin]; TLN1 protein promotes the reaction [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog results in increased susceptibility to Cisplatin]PMID:21720550
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