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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309427
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tubb2b
Name: tubulin, beta 2B class IIb
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tubb2bdecreases expressionISOTUBB2B (Homo sapiens)6480464CTDCisplatin results in decreased expression of TUBB2B mRNAPMID:27392435
Tubb2bmultiple interactionsISOTUBB2B (Homo sapiens)6480464CTDCisplatin promotes the reaction [jinfukang results in decreased expression of TUBB2B mRNA]; jinfukang promotes the reaction [Cisplatin results in decreased expression of TUBB2B mRNA]PMID:27392435
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