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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308346
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyld
Name: CYLD lysine 63 deubiquitinase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyldincreases expressionISOCYLD (Homo sapiens)6480464CTDCisplatin results in increased expression of CYLD mRNAPMID:27594783
Cyldincreases response to substanceISOCYLD (Homo sapiens)6480464CTDCYLD protein results in increased susceptibility to CisplatinPMID:21109933
Cyldmultiple interactionsISOCYLD (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of CYLD mRNAPMID:27392435
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