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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308131
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arih1
Name: ariadne RBR E3 ubiquitin protein ligase 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases response to substanceISORGD:13177266480464CTDARIH1 mutant form results in increased susceptibility to Cisplatin

PMID:25624349
increases response to substanceISORGD:13177276480464CTDARIH1 mutant form results in increased susceptibility to Cisplatin

PMID:25624349
multiple interactionsISORGD:13177266480464CTDCisplatin promotes the reaction [EIF4E2 protein binds to ARIH1 protein], Cisplatin results in increased expression of and affects the localization of ARIH1 protein

PMID:25624349
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.