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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306276
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nedd9
Name: neural precursor cell expressed, developmentally down-regulated 9
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nedd9affects response to substanceISONEDD9 (Homo sapiens)6480464CTDNEDD9 protein affects the susceptibility to CisplatinPMID:16217747
Nedd9decreases expressionISONEDD9 (Homo sapiens)6480464CTDCisplatin results in decreased expression of NEDD9 mRNAPMID:25596134
Nedd9increases expressionISONEDD9 (Homo sapiens)6480464CTDCisplatin results in increased expression of NEDD9 mRNAPMID:27594783
Nedd9multiple interactionsISONEDD9 (Homo sapiens)6480464CTDCisplatin promotes the reaction [jinfukang results in decreased expression of NEDD9 mRNA]; jinfukang promotes the reaction [Cisplatin results in decreased expression of NEDD9 mRNA]PMID:27392435
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