Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306045
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rrm2b
Name: ribonucleotide reductase regulatory TP53 inducible subunit M2B
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rrm2bdecreases expressionISORRM2B (Homo sapiens)6480464CTDCisplatin results in decreased expression of RRM2B mRNAPMID:25596134
Rrm2bincreases expressionISORRM2B (Homo sapiens)6480464CTDCisplatin results in increased expression of RRM2B mRNA; Cisplatin results in increased expression of RRM2B proteinPMID:21704725 PMID:21875941 PMID:25450742 PMID:27392435 PMID:27594783
Rrm2bincreases expressionISORrm2b (Mus musculus)6480464CTDCisplatin results in increased expression of RRM2B mRNAPMID:21151649
Rrm2bmultiple interactionsISORRM2B (Homo sapiens)6480464CTD[Cisplatin co-treated with 3-aminopyridine-2-carboxaldehyde thiosemicarbazone] results in increased expression of RRM2B protein; TP53 affects the reaction [Cisplatin results in increased expression of RRM2B protein]PMID:20954859 PMID:21875941
Go Back to source page   Continue to Ontology report