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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304927
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fam135a
Name: family with sequence similarity 135, member A
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fam135adecreases expressionISOFAM135A (Homo sapiens)6480464CTDCisplatin results in decreased expression of FAM135A mRNAPMID:27392435
Fam135aincreases expressionISOFAM135A (Homo sapiens)6480464CTDCisplatin results in increased expression of FAM135A mRNAPMID:27594783
Fam135amultiple interactionsISOFAM135A (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of FAM135A mRNAPMID:27392435
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