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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304849
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atad2
Name: ATPase family, AAA domain containing 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atad2decreases expressionEXP 6480464CTDCisplatin results in decreased expression of ATAD2 mRNAPMID:22023808
Atad2decreases expressionISOATAD2 (Homo sapiens)6480464CTDCisplatin results in decreased expression of ATAD2 mRNAPMID:27392435
Atad2decreases phosphorylationISOAtad2 (Mus musculus)6480464CTDCisplatin results in decreased phosphorylation of ATAD2 proteinPMID:22006019
Atad2increases expressionISOATAD2 (Homo sapiens)6480464CTDCisplatin results in increased expression of ATAD2 mRNAPMID:25596134 PMID:27594783
Atad2multiple interactionsISOATAD2 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of ATAD2 mRNAPMID:27392435
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