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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt3b
Name: DNA methyltransferase 3 beta
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt3bdecreases response to substanceISODNMT3B (Homo sapiens)6480464CTDDNMT3B protein results in decreased susceptibility to CisplatinPMID:18314485
Dnmt3bincreases phosphorylationISODnmt3b (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of DNMT3B proteinPMID:22006019
Dnmt3bmultiple interactionsISODNMT3B (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of DNMT3B mRNAPMID:27392435
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