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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10785
Species: Mus musculus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10increases expressionEXP 6480464CTDCisplatin results in increased expression of IL10 mRNAPMID:26546572 PMID:29191451 PMID:37769865
Il10multiple interactionsEXP 6480464CTD4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of IL10 mRNA]; [Cisplatin co-treated with vinorelbine] results in decreased expression of IL10 mRNA; Carnosine inhibits the reaction [Cisplatin results in increased expression of IL10 mRNA]PMID:21544650 PMID:26546572 PMID:29191451
Il10affects expressionISOIl10 (Rattus norvegicus)6480464CTDCisplatin affects the expression of IL10 proteinPMID:25051504
Il10decreases expressionISOIl10 (Rattus norvegicus)6480464CTDCisplatin results in decreased expression of IL10 mRNA; Cisplatin results in decreased expression of IL10 proteinPMID:27616468 PMID:32565124
Il10increases expressionISOIl10 (Rattus norvegicus)6480464CTDCisplatin results in increased expression of IL10 mRNAPMID:35842499
Il10multiple interactionsISOIl10 (Rattus norvegicus)6480464CTD2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of IL10 mRNA]; Silymarin inhibits the reaction [Cisplatin results in decreased expression of IL10 protein]; tangeretin inhibits the reaction [Cisplatin results in decreased expression of IL10 protein]PMID:27616468 PMID:32565124
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