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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of NQO1 mRNA; Cisplatin results in decreased expression of NQO1 proteinPMID:31153982 PMID:33952797
Nqo1increases expressionEXP 6480464CTDCisplatin results in increased expression of NQO1 mRNA; Cisplatin results in increased expression of NQO1 proteinPMID:20605904 PMID:21151649 PMID:24865317
Nqo1increases response to substanceEXP 6480464CTDNQO1 gene mutant form results in increased susceptibility to CisplatinPMID:26723870
Nqo1multiple interactionsEXP 6480464CTD[2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of NQO1 mRNA; [Cisplatin co-treated with Lutein] results in increased expression of NQO1 mRNA; hesperetin inhibits the reaction [Cisplatin results in decreased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [Cisplatin results in increased expression of NQO1 protein]; NQO1 gene mutant form inhibits the reaction [Cisplatin results in increased expression of ATM protein]; NQO1 gene mutant form inhibits the reaction [Cisplatin results in increased expression of PARP1 protein]; NQO1 gene mutant form inhibits the reaction [Cisplatin results in increased expression of SIRT1 protein]; NQO1 protein affects the reaction [Cisplatin results in increased expression of MRE11A protein]; NQO1 protein affects the reaction [Cisplatin results in increased expression of NBN protein]; NQO1 protein affects the reaction [Cisplatin results in increased expression of RAD51 protein]; salvianolic acid B inhibits the reaction [Cisplatin results in decreased expression of NQO1 mRNA]PMID:20605904 PMID:24865317 PMID:26723870 PMID:31153982 PMID:32428544 PMID:33952797
Nqo1affects response to substanceISONQO1 (Homo sapiens)6480464CTDNQO1 SNP affects the susceptibility to CisplatinPMID:24924344
Nqo1decreases activityISONqo1 (Rattus norvegicus)6480464CTDCisplatin results in decreased activity of NQO1 proteinPMID:25184746
Nqo1decreases expressionISONqo1 (Rattus norvegicus)6480464CTDCisplatin results in decreased expression of NQO1 mRNAPMID:33952797
Nqo1decreases expressionISONQO1 (Homo sapiens)6480464CTDCisplatin results in decreased expression of NQO1 mRNAPMID:25596134 PMID:37497868
Nqo1increases expressionISONqo1 (Rattus norvegicus)6480464CTDCisplatin results in increased expression of NQO1 mRNAPMID:18172885 PMID:22023808 PMID:33757793
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDCisplatin results in increased expression of NQO1 mRNA; Cisplatin results in increased expression of NQO1 proteinPMID:26723870 PMID:27594783 PMID:29471006 PMID:33757793
Nqo1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTDfisetin inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]; salvianolic acid B inhibits the reaction [Cisplatin results in decreased expression of NQO1 mRNA]PMID:25184746 PMID:33757793 PMID:33952797
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[Cisplatin co-treated with hesperetin] results in increased expression of NQO1 protein; astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]; Cisplatin promotes the reaction [Roflumilast results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in decreased expression of NQO1 mRNA]]; oltipraz promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]; PPARGC1A protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in decreased expression of NQO1 mRNA]]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]; SRT1720 inhibits the reaction [Cisplatin results in decreased expression of NQO1 mRNA]; sulforaphane promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]PMID:28959534 PMID:29471006 PMID:31153982 PMID:33757793 PMID:37497868
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