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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737487
Species: Homo sapiens
RGD Object: Gene
Symbol: IFNG
Name: interferon gamma
Acc ID: CHEBI:27889
Term: lead(0)
Definition: An elemental lead that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IFNGmultiple interactionsEXP 6480464CTD[Lead co-treated with IFNG protein] results in decreased expression of CD70 proteinPMID:37436718
IFNGdecreases expressionISOIfng (Mus musculus)6480464CTDLead results in decreased expression of IFNG proteinPMID:17164472
IFNGincreases expressionISOIfng (Mus musculus)6480464CTDLead results in increased expression of IFNG mRNAPMID:33483752
IFNGmultiple interactionsISOIfng (Mus musculus)6480464CTD[[lead acetate results in increased abundance of Lead] co-treated with [Lipopolysaccharides co-treated with IFNG protein]] results in increased expression of H2 protein; [lead acetate results in increased abundance of Lead] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]; [lead acetate results in increased abundance of Lead] promotes the reaction [[IL4 protein co-treated with IFNG protein] results in increased expression of MRC1 protein]; [lead chloride results in increased abundance of Lead] which results in increased expression of IFNG protein; [Lead co-treated with IFNG protein] results in decreased expression of CD70 protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IFNG protein]; Lead results in decreased expression of and results in decreased secretion of IFNG proteinPMID:28973681 PMID:30836164 PMID:34352350 PMID:37436718
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