GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MAPK3 | increases activity | EXP | | 6480464 | CTD | Lead results in increased activity of MAPK3 protein | PMID:21377791 | MAPK3 | increases phosphorylation | EXP | | 6480464 | CTD | Lead results in increased phosphorylation of MAPK3 protein | PMID:24106166 | MAPK3 | multiple interactions | EXP | | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lead results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Lead results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Lead results in increased phosphorylation of MAPK3 protein] | PMID:24106166 | MAPK3 | decreases phosphorylation | ISO | Mapk3 (Rattus norvegicus) | 6480464 | CTD | Lead results in decreased phosphorylation of MAPK3 protein | PMID:22129743 PMID:25981801 | MAPK3 | increases phosphorylation | ISO | Mapk3 (Rattus norvegicus) | 6480464 | CTD | Lead results in increased phosphorylation of MAPK3 protein | PMID:25596430 | MAPK3 | multiple interactions | ISO | Mapk3 (Rattus norvegicus) | 6480464 | CTD | [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of MAPK3 protein; [Lead co-treated with Lipopolysaccharides] results in increased phosphorylation of MAPK3 protein; Lead results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; Plant Extracts inhibits the reaction [Lead results in decreased phosphorylation of MAPK3 protein] | PMID:16044092 PMID:17298174 PMID:22129743 PMID:34350654 PMID:35307918 | MAPK3 | multiple interactions | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | [Lead co-treated with Lipopolysaccharides] results in increased phosphorylation of MAPK3 protein; chelerythrine inhibits the reaction [[Lead co-treated with Lipopolysaccharides] results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[Lead co-treated with Lipopolysaccharides] results in increased phosphorylation of MAPK3 protein] | PMID:16581537 | | ||||||||||||||||||||||
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