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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354178
Species: Homo sapiens
RGD Object: Gene
Symbol: DNMT1
Name: DNA methyltransferase 1
Acc ID: CHEBI:27889
Term: lead(0)
Definition: An elemental lead that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DNMT1decreases expressionEXP 6480464CTDLead results in decreased expression of DNMT1 mRNA; Lead results in decreased expression of DNMT1 proteinPMID:22272629
DNMT1decreases expressionISODnmt1 (Mus musculus)6480464CTDLead results in decreased expression of DNMT1 mRNA; Lead results in decreased expression of DNMT1 proteinPMID:27239543
DNMT1multiple interactionsISODnmt1 (Mus musculus)6480464CTD[lead acetate results in increased abundance of Lead] which affects the expression of DNMT1 proteinPMID:29481626
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