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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737483
Species: Mus musculus
RGD Object: Gene
Symbol: Itgb3
Name: integrin beta 3
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itgb3affects bindingISOITGB3 (Homo sapiens)6480464CTDresveratrol binds to [ITGA5 protein binds to ITGB3 protein]; resveratrol binds to ITGB3 proteinPMID:16790523
Itgb3affects localizationISOITGB3 (Homo sapiens)6480464CTDresveratrol affects the localization of ITGB3 proteinPMID:21467134
Itgb3multiple interactionsISOITGB3 (Homo sapiens)6480464CTD[ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK1 protein]; [ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK3 protein]; [ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of TP53 protein]; arginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]; resveratrol inhibits the reaction [ITGA2B protein binds to ITGB3 protein]; resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of FYN protein]; resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of GRB2 protein]; resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of PTK2 protein]; resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of SOS1 protein]PMID:16790523 PMID:21467134 PMID:26482867
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