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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736765
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1B1
Name: cytochrome P450 family 1 subfamily B member 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1B1affects expressionEXP 6480464CTDresveratrol affects the expression of CYP1B1 proteinPMID:15893423
CYP1B1affects metabolic processingEXP 6480464CTDCYP1B1 protein affects the metabolism of resveratrolPMID:15276085
CYP1B1decreases activityEXP 6480464CTDresveratrol results in decreased activity of CYP1B1 proteinPMID:11714871
CYP1B1decreases expressionEXP 6480464CTDresveratrol results in decreased expression of CYP1B1; resveratrol results in decreased expression of CYP1B1 mRNA; resveratrol results in decreased expression of CYP1B1 proteinPMID:11279601 PMID:14990334 PMID:15182955 PMID:15280659 PMID:15316568
CYP1B1multiple interactionsEXP 6480464CTD[Coumestrol co-treated with Resveratrol] results in increased expression of CYP1B1 mRNA; Resveratrol binds to and results in decreased activity of CYP1B1 protein; Resveratrol inhibits the reaction [Arsenic Trioxide results in decreased expression of CYP1B1 protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; Resveratrol inhibits the reaction [CYP1B1 protein affects the chemical synthesis of 4-hydroxyestradiol]; Resveratrol inhibits the reaction [CYP1B1 protein affects the metabolism of Estradiol]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 enhancer]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1B1 protein]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]PMID:11279601 PMID:15142886 PMID:15162144 PMID:16484233 PMID:19138946 PMID:19167446 PMID:19376845 PMID:19563207 PMID:20846786 PMID:29209748 PMID:29876539
CYP1B1decreases activityISOCyp1b1 (Mus musculus)6480464CTDresveratrol results in decreased activity of CYP1B1 proteinPMID:18420780 PMID:19329757
CYP1B1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTD[Ellagic Acid co-treated with Resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; [Glucaric Acid co-treated with Resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; [Resveratrol co-treated with Benzo(a)pyrene] results in decreased expression of CYP1B1 protein; [Resveratrol co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]PMID:18694800 PMID:20103723 PMID:30165701
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