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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735822
Species: Mus musculus
RGD Object: Gene
Symbol: Ucp1
Name: uncoupling protein 1 (mitochondrial, proton carrier)
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp1increases expressionEXP 6480464CTDresveratrol results in increased expression of UCP1 mRNA; resveratrol results in increased expression of UCP1 proteinPMID:19934007 PMID:20561979 PMID:21109418 PMID:22610192 PMID:25338179 PMID:25761413
Ucp1multiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [Resveratrol results in increased expression of UCP1 protein]; PRKAA1 gene mutant form inhibits the reaction [Resveratrol results in increased expression of UCP1 mRNA]; PRKAA1 gene mutant form inhibits the reaction [Resveratrol results in increased expression of UCP1 protein]; PRKAA1 protein promotes the reaction [Resveratrol results in increased expression of UCP1 mRNA]; PRKAA2 protein promotes the reaction [Resveratrol results in increased expression of UCP1 mRNA]PMID:19934007 PMID:25761413
Ucp1increases expressionISOUcp1 (Rattus norvegicus)6480464CTDresveratrol results in increased expression of UCP1 proteinPMID:23790948
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