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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735622
Species: Mus musculus
RGD Object: Gene
Symbol: Gdf15
Name: growth differentiation factor 15
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdf15increases expressionISOGDF15 (Homo sapiens)6480464CTD[resveratrol results in increased expression of TP53 protein] which results in increased expression of GDF15 protein; resveratrol metabolite results in increased expression of GDF15 protein; resveratrol results in increased expression of GDF15 mRNA; resveratrol results in increased expression of GDF15 proteinPMID:11895857 PMID:17257620
Gdf15multiple interactionsISOGDF15 (Homo sapiens)6480464CTD[indole-3-carbinol co-treated with resveratrol] results in increased expression of GDF15; [resveratrol results in increased expression of TP53] promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15]; Dactinomycin inhibits the reaction [resveratrol results in increased expression of GDF15 mRNA]; resveratrol promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]PMID:11895857 PMID:15670751 PMID:17257620
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