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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735188
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstk1
Name: glutathione S-transferase kappa 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstk1affects response to substanceISOGstk1 (Mus musculus)6480464CTDGSTK1 protein affects the susceptibility to resveratrolPMID:20980258
Gstk1increases expressionISOGstk1 (Mus musculus)6480464CTDresveratrol results in increased expression of GSTK1 mRNA; resveratrol results in increased expression of GSTK1 proteinPMID:20980258
Gstk1multiple interactionsISOGstk1 (Mus musculus)6480464CTDdorsomorphin inhibits the reaction [Resveratrol results in increased expression of GSTK1 protein]; FOXO1 protein affects the reaction [Resveratrol results in increased expression of GSTK1 protein]; GSTK1 protein affects the reaction [Resveratrol promotes the reaction [ADIPOQ protein binds to ADIPOQ protein]]; GSTK1 protein affects the reaction [Resveratrol results in increased expression of ADIPOQ protein]; Resveratrol promotes the reaction [PDPK1 gene mutant form results in increased expression of GSTK1 protein]PMID:20980258
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