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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732969
Species: Mus musculus
RGD Object: Gene
Symbol: Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xrcc1decreases expressionISOXrcc1 (Rattus norvegicus)6480464CTDResveratrol results in decreased expression of XRCC1 mRNAPMID:33775663
Xrcc1decreases expressionISOXRCC1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of XRCC1 proteinPMID:26046675
Xrcc1increases expressionISOXRCC1 (Homo sapiens)6480464CTDresveratrol results in increased expression of XRCC1 mRNA; resveratrol results in increased expression of XRCC1 proteinPMID:22056336
Xrcc1multiple interactionsISOXRCC1 (Homo sapiens)6480464CTDMAP2K1 protein inhibits the reaction [resveratrol results in decreased expression of XRCC1 protein]; resveratrol inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]; resveratrol inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]PMID:26046675
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