Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732483
Species: Homo sapiens
RGD Object: Gene
Symbol: NKX2-1
Name: NK2 homeobox 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NKX2-1increases expressionEXP 6480464CTDresveratrol results in increased expression of NKX2-1 mRNA; resveratrol results in increased expression of NKX2-1 proteinPMID:23594881
NKX2-1multiple interactionsEXP 6480464CTD[Plant Extracts co-treated with Resveratrol] results in decreased expression of NKX2-1 mRNA; NOTCH1 mutant form inhibits the reaction [Resveratrol results in increased expression of NKX2-1 mRNA]PMID:23557933 PMID:23594881
NKX2-1decreases expressionISONkx2-1 (Rattus norvegicus)6480464CTDresveratrol results in decreased expression of NKX2-1 mRNAPMID:28668442
Go Back to source page   Continue to Ontology report