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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732296
Species: Mus musculus
RGD Object: Gene
Symbol: Ncoa3
Name: nuclear receptor coactivator 3
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa3decreases expressionISONCOA3 (Homo sapiens)6480464CTDresveratrol results in decreased expression of NCOA3 mRNA; resveratrol results in decreased expression of NCOA3 proteinPMID:18089832
Ncoa3multiple interactionsISONCOA3 (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [NCOA3 protein binds to IL6 promoter]]; NCOA3 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; resveratrol inhibits the reaction [TNF protein inhibits the reaction [NCOA3 protein binds to IL6 promoter]]; resveratrol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]PMID:20846786 PMID:24771768
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