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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731381
Species: Mus musculus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis-inducing factor, mitochondrion-associated 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1affects localizationISOAIFM1 (Homo sapiens)6480464CTDresveratrol affects the localization of AIFM1 proteinPMID:16617056 PMID:16759640 PMID:17636462 PMID:18276737 PMID:20484155
Aifm1increases secretionISOAIFM1 (Homo sapiens)6480464CTDresveratrol results in increased secretion of AIFM1 proteinPMID:22245142
Aifm1multiple interactionsISOAifm1 (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of AIFM1 protein]PMID:19466539
Aifm1multiple interactionsISOAIFM1 (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in increased expression of AIFM1 mRNA; BAK1 protein promotes the reaction [Resveratrol results in increased secretion of AIFM1 protein]; PD 150606 inhibits the reaction [Resveratrol affects the localization of AIFM1 protein]; Resveratrol inhibits the reaction [GBA1 protein mutant form results in increased expression of AIFM1 protein]; Resveratrol inhibits the reaction [tert-Butylhydroperoxide results in increased expression of AIFM1 protein]PMID:20484155 PMID:22245142 PMID:23557933 PMID:25522270 PMID:26027833
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