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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl2decreases expressionEXP 6480464CTDResveratrol results in decreased expression of CXCL2 mRNA; Resveratrol results in decreased expression of CXCL2 proteinPMID:18277952 PMID:19228061 PMID:20117814 PMID:21192278
Cxcl2multiple interactionsEXP 6480464CTDchromium mesoporphyrin inhibits the reaction [Resveratrol results in decreased activity of CXCL2 protein]; chromium mesoporphyrin inhibits the reaction [Resveratrol results in decreased expression of CXCL2 protein]; Fulvestrant inhibits the reaction [Resveratrol results in decreased expression of CXCL2 protein]; Resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]; SB 203580 inhibits the reaction [Resveratrol results in decreased expression of CXCL2 protein]; Wortmannin inhibits the reaction [Resveratrol results in decreased activity of CXCL2 protein]PMID:15734790 PMID:18277952 PMID:20117814 PMID:21192278
Cxcl2decreases expressionISOCXCL2 (Homo sapiens)6480464CTDresveratrol results in decreased expression of CXCL2 mRNAPMID:23224687
Cxcl2decreases secretionISOCxcl2 (Mus musculus)6480464CTDresveratrol results in decreased secretion of CXCL2 proteinPMID:23514766
Cxcl2increases expressionISOCXCL2 (Homo sapiens)6480464CTDresveratrol results in increased expression of CXCL2 mRNAPMID:25888808
Cxcl2multiple interactionsISOCXCL2 (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in decreased expression of CXCL2 mRNAPMID:23557933
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