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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDresveratrol results in decreased expression of SREBF1 mRNA

PMID:23209300
multiple interactionsEXP 6480464CTD[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA], dorsomorphin inhibits the reaction [Resveratrol metabolite inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA]], Resveratrol inhibits the reaction [Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein], Resveratrol inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA], Resveratrol inhibits the reaction [High Fructose Corn Syrup results in increased expression of SREBF1 mRNA], Resveratrol inhibits the reaction [TO-901317 results in increased metabolism of SREBF1 protein], Resveratrol metabolite inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA], Resveratrol metabolite inhibits the reaction [TO-901317 results in increased metabolism of SREBF1 protein]

PMID:18239056, PMID:24633463, PMID:25238689, PMID:26973390
decreases expressionISORGD:694736480464CTDResveratrol results in decreased expression of SREBF1 mRNA

PMID:30776459
decreases expressionISORGD:694746480464CTD[resveratrol results in decreased expression of SREBF1 mRNA] which results in decreased expression of FASN mRNA, resveratrol results in decreased expression of SREBF1 mRNA, resveratrol results in decreased expression of SREBF1 protein

PMID:22659145, PMID:23090186
increases expressionISORGD:694736480464CTDresveratrol results in increased expression of SREBF1 protein modified form

PMID:22153697
multiple interactionsISORGD:694736480464CTD[Resveratrol results in increased activity of and results in increased cleavage of [SREBF1 protein co-treated with SREBF2 protein]] which results in increased expression of LDLR mRNA, ATG5 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]], BECN1 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]], Resveratrol inhibits the reaction [GW 3965 results in increased expression of SREBF1 protein], Resveratrol inhibits the reaction [Hydrocortisone results in increased expression of SREBF1 mRNA], Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein], Resveratrol inhibits the reaction [TO-901317 results in increased expression of SREBF1 mRNA], Resveratrol inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein], Resveratrol results in increased activity of and results in increased cleavage of SREBF1 protein

PMID:22153697, PMID:23651738, PMID:25943029, PMID:30776459
multiple interactionsISORGD:694746480464CTD[Resveratrol co-treated with Dietary Fats] results in decreased expression of SREBF1 mRNA, Resveratrol inhibits the reaction [Ethanol results in increased expression of SREBF1 protein], Resveratrol inhibits the reaction [Glucose results in increased expression of SREBF1 protein], Resveratrol inhibits the reaction [TO-901317 results in increased expression of SREBF1 protein]

PMID:18755807, PMID:23090186, PMID:23651738, PMID:24985011
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.