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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69271
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tcf4
Name: transcription factor 4
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tcf4multiple interactionsISOTCF4 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [Lithium Chloride results in increased activity of [TCF4 protein co-treated with CTNNB1 protein]]; resveratrol inhibits the reaction [TCF4 protein binds to CTNNB1 protein]; resveratrol results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein]PMID:22935447
Tcf4multiple interactionsISOTcf4 (Mus musculus)6480464CTDresveratrol inhibits the reaction [TCF4 protein binds to CTNNB1 protein]; resveratrol inhibits the reaction [WNT3A protein promotes the reaction [TCF4 protein binds to CTNNB1 protein]]PMID:22935447
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