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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6
Name: cytochrome P450, family 2, subfamily C, polypeptide 6
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6affects expressionEXP 6480464CTDResveratrol affects the expression of CYP2C29 mRNAPMID:15748624
Cyp2c6decreases activityISOCyp2c29 (Mus musculus)6480464CTDResveratrol results in decreased activity of CYP2C29 proteinPMID:18420780
Cyp2c6decreases activityISOCYP2C19 (Homo sapiens)6480464CTDresveratrol results in decreased activity of CYP2C19 proteinPMID:12569440
Cyp2c6multiple interactionsISOCyp2c29 (Mus musculus)6480464CTDResveratrol inhibits the reaction [titanium dioxide results in increased expression of CYP2C29 mRNA]PMID:31298478
Cyp2c6multiple interactionsISOCYP2C19 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]PMID:12569440
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