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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2810
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hnf4a
Name: hepatocyte nuclear factor 4, alpha
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hnf4amultiple interactionsEXP 6480464CTD[resveratrol promotes the reaction [FOXO1 protein binds to HNF4A protein]] which results in decreased expression of GCK mRNA; FOXO1 protein promotes the reaction [resveratrol inhibits the reaction [HNF4A protein binds to GCK promoter]]; resveratrol affects the reaction [HNF4A protein binds to GCK promoter]; resveratrol promotes the reaction [FOXO1 protein binds to HNF4A protein]PMID:19740748
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