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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2710
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Glul
Name: glutamate-ammonia ligase
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Glulincreases activityEXP 6480464CTDresveratrol results in increased activity of GLUL proteinPMID:17554623
Glulincreases expressionEXP 6480464CTDresveratrol results in increased expression of GLUL proteinPMID:16904623
Glulmultiple interactionsEXP 6480464CTD[resveratrol co-treated with Streptozocin] results in increased expression of GLUL mRNA; resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]; resveratrol inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of GLUL protein]; resveratrol inhibits the reaction [Glucose results in decreased expression of GLUL mRNA]; resveratrol inhibits the reaction [Streptozocin results in decreased expression of GLUL mRNA]; resveratrol inhibits the reaction [Streptozocin results in decreased expression of GLUL protein]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]]; zinc protoporphyrin inhibits the reaction [resveratrol results in increased activity of GLUL protein]PMID:25905778 PMID:26318273 PMID:26677078
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