Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2451
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cycs
Name: cytochrome c, somatic
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cycsdecreases expressionEXP 6480464CTDresveratrol results in decreased expression of CYCS proteinPMID:25544172
Cycsmultiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein]PMID:19466539
Cycsaffects localizationISOCycs (Mus musculus)6480464CTDresveratrol affects the localization of CYCS proteinPMID:17872969 PMID:20940732
Cycsaffects localizationISOCYCS (Homo sapiens)6480464CTDresveratrol affects the localization of CYCS proteinPMID:11577002 PMID:15827328 PMID:16095586 PMID:16617056 PMID:17116725 PMID:17636462 PMID:18276737 PMID:20484155 PMID:20697895 PMID:20717957 PMID:21505870 PMID:23724044
Cycsdecreases expressionISOCycs (Mus musculus)6480464CTDresveratrol results in decreased expression of CYCS proteinPMID:25505154
Cycsincreases expressionISOCycs (Mus musculus)6480464CTDresveratrol results in increased expression of CYCS mRNA; resveratrol results in increased expression of CYCS proteinPMID:22610192 PMID:25761413
Cycsincreases expressionISOCYCS (Homo sapiens)6480464CTDresveratrol results in increased expression of CYCS mRNAPMID:24582596 PMID:26443543
Cycsmultiple interactionsISOCycs (Mus musculus)6480464CTDdorsomorphin inhibits the reaction [Resveratrol results in increased expression of CYCS protein]; PRKAA1 gene mutant form inhibits the reaction [Resveratrol results in increased expression of CYCS protein]; Resveratrol inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]PMID:16322078 PMID:25761413
Cycsmultiple interactionsISOCYCS (Homo sapiens)6480464CTD[resveratrol co-treated with Paclitaxel] affects the localization of CYCS protein; BCL2 protein inhibits the reaction [resveratrol affects the localization of CYCS protein]; CTSD protein affects the reaction [resveratrol affects the localization of CYCS protein]; PRKN gene mutant form promotes the reaction [resveratrol results in increased expression of CYCS mRNA]; resveratrol inhibits the reaction [MFGE8 protein affects the localization of CYCS protein]PMID:11577002 PMID:14749477 PMID:17116725 PMID:21505870 PMID:24582596
Go Back to source page   Continue to Ontology report