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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2324431
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prdm16
Name: PR/SET domain 16
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prdm16increases expressionISOPrdm16 (Mus musculus)6480464CTDresveratrol results in increased expression of PRDM16 mRNA; resveratrol results in increased expression of PRDM16 proteinPMID:25761413
Prdm16multiple interactionsISOPRDM16 (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in decreased expression of PRDM16 mRNAPMID:23557933
Prdm16multiple interactionsISOPrdm16 (Mus musculus)6480464CTD[Dietary Fats co-treated with Resveratrol] results in increased expression of PRDM16 mRNA; dorsomorphin inhibits the reaction [Resveratrol results in increased expression of PRDM16 protein]; PRKAA1 gene mutant form inhibits the reaction [Resveratrol results in increased expression of PRDM16 mRNA]; PRKAA1 gene mutant form inhibits the reaction [Resveratrol results in increased expression of PRDM16 protein]PMID:25761413 PMID:29197120
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