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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [3, 4, 3', 4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]

PMID:18708364
increases localizationISORGD:7327396480464CTDresveratrol results in increased localization of ARNT protein

PMID:21756928
multiple interactionsISORGD:7327396480464CTDresveratrol inhibits the reaction [3, 4, 3', 4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]], resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]], resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]], resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]], resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]

PMID:18708364, PMID:19376845, PMID:20846786
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.