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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arntmultiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]; Resveratrol inhibits the reaction [[bisphenol A co-treated with Dietary Fats] results in increased expression of ARNT mRNA]PMID:18708364 PMID:31489946
Arntincreases localizationISOARNT (Homo sapiens)6480464CTDresveratrol results in increased localization of ARNT proteinPMID:21756928
Arntmultiple interactionsISOARNT (Homo sapiens)6480464CTDresveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]]PMID:18708364 PMID:19376845 PMID:20846786
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