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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605718
Species: Homo sapiens
RGD Object: Gene
Symbol: TFAM
Name: transcription factor A, mitochondrial
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TFAMdecreases expressionEXP 6480464CTDresveratrol results in decreased expression of TFAM mRNAPMID:12002526
TFAMincreases expressionEXP 6480464CTDresveratrol results in increased expression of TFAM mRNAPMID:21163946 PMID:21224254 PMID:24041027 PMID:24582596
TFAMmultiple interactionsEXP 6480464CTD1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of TFAM mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [Resveratrol results in increased expression of TFAM mRNA]]; [Plant Extracts co-treated with Resveratrol] results in increased expression of TFAM mRNA; Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of TFAM mRNA]; Resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TFAM mRNA]; SIRT1 protein promotes the reaction [Resveratrol results in increased expression of TFAM mRNA]; tin protoporphyrin IX inhibits the reaction [Resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TFAM mRNA]]; tin protoporphyrin IX inhibits the reaction [Resveratrol results in increased expression of TFAM mRNA]PMID:21163946 PMID:23557933 PMID:23859249 PMID:24041027
TFAMincreases expressionISOTfam (Rattus norvegicus)6480464CTDResveratrol results in increased expression of TFAM; Resveratrol results in increased expression of TFAM mRNAPMID:20429690 PMID:23790948 PMID:32619457
TFAMincreases expressionISOTfam (Mus musculus)6480464CTDresveratrol results in increased expression of TFAM mRNAPMID:17438283 PMID:21224254 PMID:22610192 PMID:24041027
TFAMmultiple interactionsISOTfam (Rattus norvegicus)6480464CTDResveratrol affects the reaction [Benzo(a)pyrene affects the expression of TFAM mRNA]; Resveratrol affects the reaction [Benzo(a)pyrene affects the expression of TFAM protein]; Resveratrol inhibits the reaction [Dietary Fats results in decreased expression of TFAM mRNA]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of TFAM protein]PMID:21632075 PMID:26770656 PMID:32619457
TFAMmultiple interactionsISOTfam (Mus musculus)6480464CTD[lipopolysaccharide, E coli O55-B5 co-treated with Resveratrol] results in increased expression of TFAM mRNA; dorsomorphin inhibits the reaction [Resveratrol results in increased expression of TFAM mRNA]; tin protoporphyrin IX inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Resveratrol] results in increased expression of TFAM mRNA]; tin protoporphyrin IX inhibits the reaction [Resveratrol results in increased expression of TFAM mRNA]PMID:17438283 PMID:24041027
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