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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593534
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mat2b
Name: methionine adenosyltransferase 2 non-catalytic beta subunit
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mat2bincreases expressionISOMAT2B (Homo sapiens)6480464CTDresveratrol results in increased expression of MAT2B mRNAPMID:23814050
Mat2bmultiple interactionsISOMAT2B (Homo sapiens)6480464CTD[resveratrol co-treated with NADP] binds to MAT2B protein; ELAVL1 mutant form inhibits the reaction [resveratrol results in increased expression of MAT2B protein]; MAT2B mutant form inhibits the reaction [resveratrol results in increased expression of ELAVL1 protein]; MAT2B mutant form inhibits the reaction [resveratrol results in increased expression of FOXO3 protein]; MAT2B mutant form inhibits the reaction [resveratrol results in increased expression of SIRT1 protein]; resveratrol inhibits the reaction [MAT2B protein binds to MAT2A protein]; resveratrol promotes the reaction [ELAVL1 protein binds to MAT2B mRNA]; resveratrol promotes the reaction [MAT2B protein binds to ELAVL1 protein]; resveratrol promotes the reaction [MAT2B protein binds to SIRT1 protein]; resveratrol results in increased expression of and results in increased stability of MAT2B mRNA; resveratrol results in increased expression of and results in increased stability of MAT2B protein; SIRT1 mutant form inhibits the reaction [resveratrol results in increased expression of MAT2B mRNA]; SIRT1 mutant form inhibits the reaction [resveratrol results in increased expression of MAT2B protein]PMID:23814050 PMID:25526675
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