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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552455
Species: Mus musculus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasincreases expressionEXP 6480464CTDresveratrol results in increased expression of FAS mRNA; resveratrol results in increased expression of FAS proteinPMID:17872969 PMID:22610192
Fasaffects localizationISOFAS (Homo sapiens)6480464CTDresveratrol affects the localization of FAS proteinPMID:12902349
Fasincreases expressionISOFAS (Homo sapiens)6480464CTDresveratrol analog results in increased expression of FAS mRNA; resveratrol results in increased expression of FAS mRNA; resveratrol results in increased expression of FAS proteinPMID:17261084 PMID:19846903 PMID:24044363 PMID:26341291
Fasincreases expressionISOFas (Rattus norvegicus)6480464CTDresveratrol results in increased expression of FAS mRNAPMID:20797428
Fasincreases response to substanceISOFAS (Homo sapiens)6480464CTDFAS protein results in increased susceptibility to resveratrol; resveratrol results in increased susceptibility to FAS proteinPMID:19561642 PMID:20097879
Fasmultiple interactionsISOFAS (Homo sapiens)6480464CTD[allyl sulfide co-treated with resveratrol] results in increased expression of FAS protein; [IFNG protein results in increased expression of and results in increased localization of FAS protein] which results in increased susceptibility to resveratrol; Capsaicin promotes the reaction [resveratrol results in increased expression of FAS protein]; Nystatin inhibits the reaction [resveratrol affects the localization of FAS protein]; resveratrol promotes the reaction [FAS protein binds to CASP10 protein]; resveratrol promotes the reaction [FAS protein binds to CASP8 protein]; resveratrol promotes the reaction [FAS protein binds to FADD protein]PMID:12902349 PMID:18512326 PMID:19561642 PMID:19846903
Fasmultiple interactionsISOFas (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of FAS mRNA]; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of FAS protein]PMID:23127599
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