Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350530
Species: Homo sapiens
RGD Object: Gene
Symbol: SRC
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SRCaffects phosphorylationEXP 6480464CTDresveratrol affects the phosphorylation of SRC proteinPMID:22634503
SRCdecreases phosphorylationEXP 6480464CTDresveratrol results in decreased phosphorylation of SRC proteinPMID:26138072 PMID:26911335
SRCincreases activityEXP 6480464CTDresveratrol results in increased activity of SRC proteinPMID:15615701
SRCincreases phosphorylationEXP 6480464CTDresveratrol results in increased phosphorylation of SRC proteinPMID:17513867 PMID:18296501
SRCmultiple interactionsEXP 6480464CTD[Resveratrol affects the phosphorylation of SRC protein] affects the reaction [sodium arsenite results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]]; [Resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]] which results in increased abundance of Nitric Oxide; AG 1879 inhibits the reaction [Resveratrol results in increased phosphorylation of SRC protein]; ESR1 protein promotes the reaction [Resveratrol results in increased phosphorylation of SRC protein]; Resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]; Resveratrol results in decreased phosphorylation of and results in decreased activity of SRC proteinPMID:16546976 PMID:17513867 PMID:18296501 PMID:22634503
SRCdecreases phosphorylationISOSrc (Mus musculus)6480464CTDresveratrol results in decreased phosphorylation of SRC proteinPMID:26138072
SRCmultiple interactionsISOSrc (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of SRC protein]; resveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of SRC protein]PMID:24079413 PMID:26621445
SRCmultiple interactionsISOSrc (Mus musculus)6480464CTD[Resveratrol co-treated with Glucose] results in decreased expression of SRC mRNA; [Resveratrol co-treated with Glucose] results in decreased expression of SRC protein; [Resveratrol co-treated with Glucose] results in decreased expression of SRC protein modified form; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]; Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]]PMID:24659233 PMID:26100520
Go Back to source page   Continue to Ontology report