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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Adecreases expressionEXP 6480464CTDresveratrol results in decreased expression of HSPA1A mRNA; resveratrol results in decreased expression of HSPA1A proteinPMID:18089832 PMID:20090934
HSPA1Amultiple interactionsEXP 6480464CTD[resveratrol results in decreased phosphorylation of GSK3B protein] which results in decreased expression of HSPA1A proteinPMID:20090934
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTDResveratrol inhibits the reaction [titanium dioxide results in increased expression of HSPA1A mRNA]PMID:31298478
HSPA1Amultiple interactionsISOHspa1a (Rattus norvegicus)6480464CTDresveratrol promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPA1A mRNA]PMID:26361869
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