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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315921
Species: Homo sapiens
RGD Object: Gene
Symbol: ERCC1
Name: ERCC excision repair 1, endonuclease non-catalytic subunit
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ERCC1affects response to substanceEXP 6480464CTDERCC1 protein affects the susceptibility to resveratrolPMID:23912706
ERCC1multiple interactionsEXP 6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [resveratrol results in increased expression of ERCC1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [resveratrol results in increased expression of ERCC1 protein]; Pemetrexed inhibits the reaction [resveratrol results in increased stability of and results in increased expression of ERCC1 mRNA]; Pemetrexed inhibits the reaction [resveratrol results in increased stability of and results in increased expression of ERCC1 protein]; resveratrol results in increased stability of and results in increased expression of ERCC1 mRNA; resveratrol results in increased stability of and results in increased expression of ERCC1 proteinPMID:23912706
ERCC1decreases expressionISOErcc1 (Rattus norvegicus)6480464CTDResveratrol results in decreased expression of ERCC1 mRNAPMID:33775663
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