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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311875
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdc25c
Name: cell division cycle 25C
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdc25cdecreases expressionEXP 6480464CTDResveratrol results in decreased expression of CDC25C mRNAPMID:33775663
Cdc25cincreases phosphorylationISOCDC25C (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of CDC25C proteinPMID:15975956
Cdc25cmultiple interactionsISOCDC25C (Homo sapiens)6480464CTD[Coumestrol co-treated with resveratrol] results in increased expression of CDC25C mRNA; [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] which results in increased phosphorylation of CDC25C protein; Caffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDC25C protein]PMID:15975956 PMID:19167446
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