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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307616
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Yars1
Name: tyrosyl-tRNA synthetase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Yars1affects localizationISOYARS1 (Homo sapiens)6480464CTDResveratrol affects the localization of YARS1 proteinPMID:25533949
Yars1multiple interactionsISOYARS1 (Homo sapiens)6480464CTD[Resveratrol promotes the reaction [PARP1 protein binds to YARS1 protein]] which results in increased ADP-ribosylation of PARP1 protein; Resveratrol binds to and results in decreased activity of YARS1 protein; Resveratrol promotes the reaction [PARP1 protein binds to YARS1 protein]; YARS1 protein affects the reaction [Resveratrol results in increased acetylation of TP53 protein]; YARS1 protein affects the reaction [Resveratrol results in increased ADP-ribosylation of PARP1 protein]PMID:25533949
Yars1multiple interactionsISOYars1 (Mus musculus)6480464CTD1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one inhibits the reaction [Resveratrol promotes the reaction [PARP1 protein binds to YARS1 protein]]; Resveratrol promotes the reaction [PARP1 protein binds to YARS1 protein]PMID:25533949
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